Kubva kuValencia, timu kubva kuYunivhesiti Clinical Hospital uye INCLIVA Health Research Institute iri kuongorora kuti sei kunyatsogadzirisa lipid control Tsvagiridzo inotarisa kune varwere vanotevera chirwere chemoyo kudzivirira zvimwe zviitiko zvecoronary. Chidzidzo ichi chine chinangwa chekushandura zvakawanikwa kuita zvekiriniki.
Zvidzidzo izvi zvinoongorora matatu anopindirana mativi: iwo chaiwo maitiro eiyo kuchinja mararamiro uye mishonga paLDL cholesterol, kushanduka kweHDL cholesterol panguva yekuvandudza uye kuongororwa kwe mhuri hypercholesterolemia mune vakapukunyuka acute myocardial infarction.
Mitsara yekutsvagisa mukudzora lipid mushure mekurova kwemoyo
Chikwata chekiriniki-tsvakurudzo, chinotungamirirwa na Victor Marcos Garces rinotevera Carlos BertolĂn Boronat y Hector Merenciano Gonzalez, chikamu cheKushandura Kwekutsvagisa Group muIschemic Heart Disease ye INCLIVA neCIBER CB16/11/00486, yakarongedzwa naProfessor Vicente BodĂ PerisMitsetse yekutsvagisa inogadzirisa zvese biological mhinduro kune lipid-kudzikisa zvinodhaka uye marongero e mishonga yemunhu mukudzivirira kwechipiri.
Kuti vaite izvi, vakavimba nekubatanidzwa kweCardiology uye Rehabilitation Services yechipatara pachayo, INCLIVA Biobank, uye kubatana kweboka reCIBER. CB16/11/00360, inotungamirirwa na Manuel Francisco Jiménez Navarro, Pedyo ne FIMABIS uye Virgen de la Victoria University Hospital muMalaga, nekudaro kusimbisa network yekushanda ine tarisiro multicenter.
LDL: Kana mararamiro asina kukwana
Muchidzidzo chakaburitswa mu Journal of Clinical Medicine, pamwe 179 post-infarction varwere Mushure mekupedza chikamu chechipiri chekugadzirisa, zvakaonekwa kuti, pasinei nekuteerera kwakanaka kudya kunovaka mwoyo uye kurovedza muviri, kumativi a chechitatu hachisviki kuderedzwa kweLDL kunokarirwa nokurapa kwakarongwa.
Vanyori vanosimbisa kuti chimiro ichi chinogona kuratidza kusiyana-siyana mukupindura kune lipid-kudzikisa zvinodhaka uye yekutanga LDL mazinga ayo akaoma kuenzanisa kuburikidza nemararamiro ega. Mumamiriro ezvinhu aya, vanokurudzira kudzivisa kupomera murwere uye simbisa kurapwa kana zvichiratidzwa, zvichipiwa kuti, kunyange nekugadzirisa, chinangwa cheLDL chinowanikwa zvishoma nezvishoma muboka iri.
HDL panguva yekugadziriswa kwemoyo
Chidzidzo chechipiri, chakabudiswa muOngororo muCardiovascular Medicine, yakatevera 121 varwere uye akatsanangura kuvandudzwa kunoonekwa muHDL cholesterol mukati meCardiac Rehabilitation Program. Kuwedzera kwacho kwainyanya kukosha vaimbosvuta uye mune avo vakaderedza cholesterol yakazara neLDL cholesterol zvakanyanya.
Zvinoenderana nemhedzisiro, HDL, kunyangwe ichionekwa sechipiri chekudzora chinangwa, inogona kubatsirwa kubva mukusanganiswa kwe kurovedza muviri uye kuchinja kwemaitiro. Nekudaro, vanhu vane yakakwirira baseline HDL mazinga uye yakakwira manhamba e lipoprotein (a) yakaratidza mukana wakaderera wekuvandudzwa kwakasiyana.
Kuongororwa kwemhuri hypercholesterolemia mushure mekurwadziwa kwemoyo
Chidzidzo chechitatu, chakaburitswa muCardiogenetics, chakaongorora mukana wekuongorora wemhuri hypercholesterolemia mu. 245 vakapona nechirwere chemoyo kurapwa mukugadzirisa. Zvikamu zviviri muzvitatu zvakapa mukana wakaderera, asi mune yakasara kuongororwa kwaive "zvinogoneka" kana "zvinogoneka" ichitevera nzira yeDutch Lipid Clinic Network (DLCN).
Kunyange zvakadaro, dzakaitwa zvishoma zvidzidzo zvemajiniIzvi zvinoratidza nzvimbo yakajeka yekuvandudza. Chikwata chinokurudzira kuenzanisa kushandiswa kweiyo DLCN maitiroOngorora / fungidzira yekutanga mazinga eLDL uye tungamira kuongororwa kwemajini kune varwere vane mukana wakakura wekuvandudza mamiriro acho, kugadzirisa kurapwa uye kufambisa kudzivirira mumhuri.
Kushambadza uye mari
Zvakawanikwa zvakanyorwa mukati Zvinyorwa zveKiriniki Mushonga, Wongororo muCardiovascular Medicine y CardiogeneticsPakati pevakasaina ndiVĂctor Marcos GarcĂ©s, Carlos BertolĂn Boronat, naHĂ©ctor Merenciano González, mukati meiyo INCLIVA ischemic chirwere chemoyo boka uye chimiro. CIBERCV inotungamirwa naVicente BodĂ Peris paYunivhesiti yeValencia.
Mapurojekiti aya akawana rutsigiro kubva Carlos III Health Institute, Funds ERDF and the FSE+: rubatsiro PI20/00637, PI23/01150, CIBERCV16/11/00486, pamwe neCM23/00246 yakapihwa Hector Merenciano Gonzalez uye CM21/00175 uye JR23/00032 kuna Victor Marcos Garces.
Zvinoreva kune varwere uye hutano hwehutano
Mune mamiriro ekuwedzera kudiwa kweLDL zvibodzwa muEurope, iyi data inotsigira nzira proactive uye personalized Mushure mekurwadziwa kwemoyo: sanganisa kupindira kwehupenyu nekuwedzera kwemishonga kana zvichidikanwa uye tora mukana wekuvandudza moyo tarisa uye gadzirisa.
Kuvandudzwa kuongororwa kwemhuri hypercholesterolemia kunogona kutyaira nzira dze cascade kuona uye kurapa kunoshanda zvakanyanya, zvine chekuita nekudzokera shure uye mutoro wehutano. Kubatanidza matanho aya mukugadzirisa nzira kunofambisa nzira inoshanda. yakarongeka uye yakaenzana kune varwere vepashure-moyo.
Zvidzidzo zvitatu izvi zvinosimbisa kuti kutonga kweLDL kunoda kuwedzera kwekurapa pasina rusarurakuti HDL inogona kuvandudza nekugadzirisa uye kuti kuongororwa kwemajini kunofanira kurongeka; mugwagwa unobatsira wecardiology uye masevhisi ehutano hweveruzhinji ari kutsvaga kudzikisira kurwisa kwemoyo uye matambudziko muSpain.
