Kuverenga kutsva kwe SELECT Clinical trial inosanganisa iyo Ozempic-type mishonga, zvichibva pa semaglutide, kupa kuchengetedzwa kwemoyo muvanhu vane uremu kana kuti vakafutisa vanototambura nechirwere chemoyo. Mhedzisiro, yakaburitswa muThe Lancet, inosimbisa kuti mhedzisiro yacho kupfuura kuderedza uremu, chinhu chinokosha chekudzidzira kwekliniki.
Mukuongorora uku, mushonga wacho wakaderedza zvakanyanya kuipa kwakashata zviitiko zvemoyo, nekudonha mukati 20% mukurwadziwa kwemoyo, sitiroko kana kufa kwemoyoKuvandudzwa kwacho kwaisaenderana nekuti makirogiramu mangani mumwe nemumwe akarasika uye, kutaura zvazviri, kuderedzwa kwechiuno chechiuno kunongotsanangurwa zvakapoteredza. chikamu chimwe muzvitatu chemhindu yese.
Zvinounzwa netsvakiridzo yeSARUDZA
SARUDZA zvinosanganisirwa vanhu vanopfuura 17.600 vanopfuura makore makumi mana nemashanu, ine body mass index (BMI) ≥27 uye yakasimbisa chirwere chemwoyo, yakatorwa munyika dze41. Vatori vechikamu, vose vasina chirwere cheshuga, vakagamuchira majekiseni evhiki nevhiki e semaglutide kana placebo uye yakateverwa kweanopfuura makore maviri.
Kuenzaniswa ne placebo, semaglutide yakaderedza zviitiko zvakakomba zvemoyo (MACE) ne 20%Mhedzisiro iyi yaienderana zvisinei nehuremu hwekutanga uye huwandu hwehuremu hwakarasika pakutevera, zvichisimbisa kuti kudzivirira Hazvitsanangurwi chete nekuderedza uremu.
Kuongorora kwakaparadzanisa basa rekuyera uye kutenderera kwechiuno. Nepo shanduko muhuremu hwaive nehuremu hushoma hwekufungidzira, kudzikiswa kwega kwega kweinenge 5 centimita muchiuno kwakabatana nekudonha kweanenge. 4% munjodzi yemoyo, kutsanangura nezve 33% yekubatsira kwekurapa; yasara inonongedzera kune dzimwe nzira.
Sekureva kwechikwata chinotungamirwa naJohn Deanfield (UCL), mafuta emudumbu anonyanya kukuvadza kumoyo uye kudzikisira kwakakosha, asi kuchine. zvikamu zviviri muzvitatu zvekudzivirira pasina nzira imwe chete yekuitsanangura. Izvi zvinovhura musuwo wekutungamira nzira dzemoyo dze semaglutide mumatishu nemidziyo.
Nzira dzinogona kuitika kunze kwechiyero
Semaglutide is a GLP-1 receptor agonist, nzira yehomoni inodzora kudya uye shuga yeropa mushure mekudya. Kunze kwekudzora uremu, humbowo hunoratidza maitiro akanaka pane vascular kuzvimba, endothelial basa uye hemodynamic uye lipid parameters.
- kushoma kuzvimba: kuderera kweproinflammatory cytokines inokuvadza tsinga.
- Zvirinani BP uye lipids: kunaka kunobatsira pakunetsana uye HDL cholesterol uye LDL.
- Endothelial basa zvakanyanya kugona: midziyo ine nani dilation kugona.
Kune Deanfield, izvi mhedzisiro "reconfigure" chiratidzo chemushonga: haingangove kurapa kwekurasikirwa uremu, asiwo. mudziyo wekudzivirira moyo zvakananga kune varwere vane chirwere chakasimbiswa.
Clinical zvinoreva muSpain neEurope
Nyanzvi munharaunda yedu, dzakadai Antonia Delgado (Gregorio Marañón Hospital), inoratidza kuti perimita yedumbu inoratidza mafuta e-visceral, ayo akanyatsobatanidzwa nekurwadziwa kwemoyo uye sitiroko. José Luis Zamorano (Ramón y Cajal Hospital), iyo data inotsigira cardioprotective mhedzisiro yayo; uye Cristóbal Morales (Vithas Sevilla Hospital) inosimbisa kukosha kwayo mukudzivirira kwemoyo muvarwere vane BMI ≥27 uye chirwere chemoyo.
Kana yakasimbiswa uye ichiendeswa kune mazano, semaglutide inogona wedzera chiratidzo chayo kune maprofiles ane huremu hwepamusoro nenjodzi yemoyo, kunyangwe ivo vasina kuwana uremu hwakakosha. MuEurope, mamwe maitiro ehutano atanga ongorora kushandiswa kwayo neiyi nzira, nepo muSpain mari yayo inogoneka mune yechipiri kudzivirira mamiriro ari kukakavara.
Izvo zvinogona kukanganisa hutano zvakakosha: zvirwere zvemoyo zvinoramba zviri izvo chikonzero chikuru chekufa munyika yedu. Mushonga unokwanisa kuderedza zviitiko zvakakomba kune varwere vane chirwere chakasimbiswa, pasinei nekurema kwakarasika, kunomiririra mukana we kuderedza mutoro wekutarisira uye kuvandudza hupenyu hwehupenyu, uye hunogona kuenderana nehunyanzvi hwakadai sea wachi inoona kurova kwemoyo.
Kuganhurirwa uye kungwarira
SELECT haina kusanganisira vanhu vane chirwere cheshuga uye yaiva inotsigirwa neNovo Nordisk, mugadziri wemushonga. Uyezve, boka racho rakanga rine misiyano mishoma—varume vachena vainyanya—saka zvinoda kuongororwa nebonde uye dzinza uye mamwe data mune mamwe mapoka.
Parizvino, humbowo hwakasimba hunogumira kune vanhu vakuru vane BMI ≥27 uye yakagadziriswa chirwere chemwoyo. Inoshandiswa muvanhu vasina huremu hwakawandisa kana mukutanga kudzivirira kudiwa miedzo chaiyo tisati tafunga kuchinja kukuru kwechiratidzo.
Mufananidzo wakazara wakasiiwa neSETA data wakajeka: Ozempic-mhando mishonga inopa zvakakosha zvemoyo zvinobatsira muvarwere vasina chirwere cheshuga uye vane uremu hwepamusoro kana kufuta, uye izvi hazvibvi pane nhamba pachiyero; iyo waistline inokosha, asi haitsananguri zvose, izvo zvinonongedza cardiometabolic mechanisms tsvakiridzo iyoyo yatotanga kubuda pachena.