Chikwata che Sant Pau Research Institute (IR Sant Pau) yeBarcelona yakatsanangura nzira yehupenyu inobatsira kunzwisisa zviri nani kuti sei cholesterol inoungana mutsinga uye nei mamwe maplaque achiguma ave nengozi kupfuura mamwe. Ichi chiwanikwa chikamu cheongororo yeatherosclerosis, chirwere chisingaperi chemoyo chinoramba chiri chimwe chezvikonzero zvinotungamira zvekufa muEurope.
Mhedzisiro, yakaburitswa mujenari resainzi MaseroVanonongedza kuzadzisa C3, puroteni yakakosha ye immune system, semutambi wepakati mu kushanduka kwezvironda zve atheroscleroticKupfuura basa rayo rekutanga mukudzivirira kubva kuhutachiona, molekuru iyi inotora chikamu zvakananga mumaserura shanduko inoita kuti cholesterol plaque iwedzere kutetepa uye inokwanisa kuputika.
Basa risingatarisirwi rekuzadzisa C3 mu atherosclerosis
Atherosclerosis inoratidzirwa ne kuunganidzwa kwecholesterol nezvimwe zvinhu mumadziro etsingaIzvi zvinokonzeresa mhinduro yekuzvimba inoenderera. Nekufamba kwenguva, kusanganiswa kwe lipids uye kuzvimba kunoita kuti vascular tissue igadzirise uye irasikirwe nechiyero chayo uye simba remagetsi.
Muchirevo chechinyorwa ichi, boka re Biomarkers yeCardiovascular Disease Evolution pa IR Sant Pau Tsvagurudzo yakanangana nekuzadzisa C3, puroteni yepakati peiyo complement system. Nechinyakare yaizivikanwa nebasa rayo mukusabatwa nemuviri, iko zvino yave kuratidzwa kuti inewo yakanangana nekukanganisa maseru anoumba arterial wall.
Maererano nemuongorori mukuru wezvidzidzo, Teresa PadróChidzidzo chacho chinozivisa basa idzva rekuzadzisa C3 rinobatanidza maitiro ezvirwere zvemuviri kune masero emagetsi anogadzirisa tsinga. Izvi zvinopa maonero akabatanidzwa ekuti sei Kuzvimba uye lipids "inofambidzana" kusimudzira kufambira mberi kwechirwere.
Chidzidzo chacho chinoratidza kuti, kana yaitwa, iyo C3 mubatsiri inobatsira atherosclerotic maronda anowedzera kusagadzikana uye anowanzo kuputikaKusagadzikana uku kunonyanya kunetseka nokuti kuputika kweplaque kunogona kukonzera kuumbwa kwethrombus uye, nokudaro, kunokonzera myocardial infarction kana sitiroko.
Vanyori vanosimbisa kuti kunzwisisa iyi itsva molecular axis inobvumira kunzwisisa kuri nani kwechikonzero nei, mune vamwe vanhu, mapepa achifambira mberi. mamwe mafomu ane ngozi nyangwe control classic factors senge cholesterol yeropa kana BP, chinhu chinonakidza kuEuropean cardiology.
Smooth muscle cells, pakati pekuchinja
Mukati me arterial wall, the vascular smooth muscle cells Vanoita basa rinokosha. Mumamiriro ezvinhu akajairika, vanoita semasero echibvumirano, vachibatsira kuchengetedza kusimba kwemudziyo weropa uye kugadzirisa vascular tone. Nekudaro, mukupindura kuzvimba kana lipid stimuli, vanogona kuchinja maitiro avo.
Basa reIR Sant Pau rinoratidza kuti activation yeC3 mubatsiri inokonzeresa a nhevedzano yekuchinja mumasero aya akatsetseka emhasuruIvo vanorega kuita semaseru echibvumirano uye kuwana imwe nharembozha, ine hukuru hukuru hwekugadzirisa matrix inovatenderedza uye kutora chikamu mukuumbwa kweiyo atherosclerotic plaque.
Iyi shanduko mukuzivikanwa kwemaserura haisi, pachayo, yakaipa: chikamu che nzira dzekugadzirisa zvisikwa yemudziyo kana yaparara. Dambudziko rinomuka kana maitiro aya akareba munzvimbo yakaremerwa necholesterol uye varevereri vanopisa, chimwe chinhu chinozivikanwa muatherosclerosis yepamusoro.
Muchiitiko ichocho, masero akatsetseka emhasuru anogona kubatsira kwete chete kukurisa madziro e arterial, asiwo kune chimiro cheplate yakanyanya kutetepaine chifukidziro chine fibrous yakatetepa uye yakanyanya kusununguka. Mhando dzekukuvadzwa idzi ndidzo dzinonyanya kutsemuka kana kuputika.
Saka chidzidzo chinopa a tsananguro yakadzama kuti nzira dzekudzivirira dzemuviri dzinopindirana sei nemaitiro ekugadzirisa vascular, pfungwa iyo kusvika ikozvino yakanga isati yanyatsojekeswa mumabhuku esayenzi.
Iyo iC3b fragment uye kurongekazve kwemukati kwesero
Chimwe chezvinhu zvakakosha zvakaonekwa nechikwata chidimbu chakabatiswa cheplugin chinozivikanwa se iC3bIyi molecule inogadzirwa kana C3 yashandiswa uye inoita sechiratidzo chinogadzirisa mukati memasero akatsetseka emhasuru ye arterial wall.
Vatsvakurudzi vakaona kuti iC3b inokwanisa shandura sangano remukati remasero ayakupesvedzera kuti vanonamatira sei kunharaunda yavo uye mafambiro avanoita mukati memadziro emudziyo. Kuchinja kwesero maitiro kwakabatana zvakananga nekufambira mberi kweatherosclerotic maronda.
Kunyanya, chidzidzo chinotarisa pane paxillin (PXN)Paxillin ipuroteni yakakosha panzvimbo yekunamatira maseru inogadzirisa kutaurirana kwesero nematrix akatenderedza. Inoshanda sechiratidzo chepuratifomu, inotungamira sero chimiro, motility, uye kugadzikana.
Ichishandisa nzira dzepamusoro dzemicroscope, timu yakasimbisa kuti kana masero akatsetseka emhasuru aiswa pachena aggregated low-density lipoproteins (LDL-ag), chimiro chakagadziridzwa cheiyo inonzi "yakaipa" cholesterol inowanzowedzera kuunganidza mutsinga, kune kuderedzwa kwehuwandu hwepaxillin uye kuchinja kunoshamisa mukuparadzirwa kwayo mukati mesero.
Uku kusanganiswa kweIC3b uye agLDL kunotungamira kune a kurongekazve kwakadzikama kwema cellular architectureIzvi zvinofambisa masero akatsetseka emhasuru anotora imwe inotama uye kugadzirisazve phenotype. Nenzira iyi, maplaques anowanzo shanduka kuita nyika dzepamberi uye dzisina kugadzikana, kuwedzera njodzi yemoyo.
Kuzvimba, lipids, uye arterial kugadzikana
Migumisiro yebasa inosimbisa pfungwa yokuti Atherosclerosis yakawanda kupfuura kungoisa mafuta mashoma mutsinga. Iyo isimba rekuita umo lipids, immune system masero, vascular wall masero, uye akawanda anopisa anopindirana anopindirana.
Iyo plugin system, uye kunyanya C3 uye chidimbu chayo iC3b, ikozvino inoratidzika se kubatana pakati pekudzivirira kwekudzivirira uye vascular remodelingIyo haingobatanidzi chete mumhinduro yekuputika kwekare, asiwo inogadzirisa chimiro, maitiro uye kugadzikana kwemasero anotsigira chimiro che arteri.
Muchirevo cheEurope, apo iyo Zvirwere zvemwoyo zviri kuramba zvichinyanya kukonzera rufuKunzwisisa nzira idzi dzakajeka kuri kuwana kukosha kwekliniki. Iko mukana wekupindira kwete chete pamazinga echolesterol, asiwo pakugadzikana kweplaque uye mhinduro yakabatana yekuzvimba, inovhura nzira nyowani dzekudzikisa zviitiko zvakaita sekurwadziwa kwemoyo uye sitiroko.
Vanyori vekudzidza vanoratidza kuti iyi nyowani mamorekuru axis inogona kubatsira kutsanangura kuti sei, mune vamwe varwere, maplaques achinyanya kuve panjodzi kunyangwe kudzora zvine musoro kwezvinhu zvengozi. Rudzi urwu rweruzivo runogona kuve runokosha ku kunatsa njodzi stratification uye wedzera gadzirisa iyo yekutevera.
Uyezve, basa rinoisa iyo C3 inopindirana sezvinobvira chinangwa cheramangwana chekurapaKugadzirisa kushandiswa kwayo kana kuvharidzira zvakanangana neC3b pamasero akatsetseka emhasuru anogona, muchirevo, kubatsira mukusimbisa kugadzikana kwemagetsi etsinga pasina kupindira zvakanyanya kudzivirira kwese kwedziviriro.
Zvinorehwa nemaitiro matsva ekurapa
Kuti unzwisise zvakadzama kuti C3 uye iC3b plugins inopesvedzera sei iyo kugadzikana kwecholesterol plaques Izvi zvinotibvumira kufunga mamwe marapirwo chaiwo. Kupfuura mishonga yakajairwa yakanangana nekudzikisa cholesterol kana systemic kuzvimba, kupindira kunogona kugadzirwa kunonangana nemaserura maitiro anogadzirisa madziro e arterial.
Vatsvagiri veI IR Sant Pau vanonongedza kuti, zvichibva paruzivo urwu, zvinogoneka kuongorora maitiro ayo kwete chete kuderedza lipid mutoroasi zvakare simbisa iyo fibrous yekuvhara ye plaques uye kuvandudza kugona kwe arteries kutsungirira zuva nezuva mechanical kusagadzikana.
Nhungamiro dzenguva yemberi dzinosanganisira marapirwo angangove anosarudzika kusaina iC3b kana kudzivirira mapuroteni akakosha akadai sepaxillin, kuitira kudzivirira masero emhasuru anotsvedzerera kuti asatore zvakanyanya kutama phenotype uye destabilizing.
Iyi mhando yemaitiro inoenderana neyazvino maitiro e cardiology yekubatanidza ane simba lipid-kuderedza marapirwo (zvakadai sema statins kana PCSK9 inhibitors) ane dzimwe nzira dzakanyatso kurwisa-kupisa. Uyezve, kubatanidza kutonga kwemaitiro ekugadzirisa arterial kunogona kupa kuchengetedzwa kwakawedzerwa kune varwere vane njodzi.
Muchidimbu, chidzidzo chakaitwa muBarcelona chinowedzera chimwe chidimbu kune yakaoma puzzle yeatherosclerosis, inoratidza sei a classic immune system protein Inogona kuva nemigumisiro yakasimba pakuvakwa kwetsinga uye pakushanduka kwekliniki yechirwere.
Zvese zvinoratidza kuti, sezvatinozama zvakadzama mumhando idzi dzemaitiro, zvinogoneka kugadzira mamwe marapirwo akarongedzerwa ayo asingangodzikisi cholesterol, asi zvakare anotarisa pa. kuita kuti mahwendefa awedzere kugadzikana uye asingatani kuputsika, nechinangwa chekupedzisira chekudzikisa zvakanyanya zviitiko zvakakomba zvemwoyo muhuwandu hwevanhu.