Tsvagiridzo yenzira mbiri dzekutaurirana pakati peguyo system uye tsinga system iri kusangana nekuwedzera muEurope neSpain. Mumwedzi ichangopfuura, mitsetse yakawanda yebasa yakapa data inobatanidza iyo intestinal microbiota, metabolites uye mahomoni nemafungiro, kuziva uye maitiro.
Kunze kwetsananguro dzakareruka, humbowo huchangobva kuitika hunoratidza izvozvo mararamiro, kudya uye kurovedza muviri Vanotaurirana nehuropi kuburikidza nemaitiro chaiwo emamorekuru. Kubva MaSpanish cohorts ane electroencephalogram Kubva kune preclinical modhi muIreland, gut-brain axis inosimbiswa senzvimbo yakakosha yekunzwisisa hutano hwepfungwa nekuchembera.
Chii chinonzi gut-brain axis uye nei zvine basa?
Iyo gut-brain axis ndeyekutaurirana network inosanganisira yepakati uye enteric nervous system, immune system, akawanda mahomoni, uye microbiotaZvinyorwa zvesainzi zvinotsanangura vayananisi vakaita se short-chain mafuta acids, tryptophan metabolites uye kuisa chiratidzo kuburikidza neve vagus nerve, inokwanisa kupesvedzera neurotransmitters, kuzvimba, uye kushushikana kupindura.
Zvinofungidzirwa kuti chikamu chakakura chekuzvidzivirira kwemuviri chinogara muura uye kuti, kubva pamatanho ekutanga ehupenyu, inosarudza. kudya, kurara, uye kugadzirisa kunetseka chimiro chezuva nezuva icho chakasiyana chimiro chemicroorganisms icho, kana chisina kuenzana, chinogona kuve chine chekuita nekusagadzikana kwekugaya uye shanduko mune mamiriro emanzwiro.
Huchapupu huchangobva kuitika kubva kuEurope: kudya, kurovedza muviri, uye metabolism
Muchidzidzo chakabva kuUniversity College Cork (Ireland), kurovedza muviri kwokuzvidira kwakapesana nemaitiro ekuora mwoyo-semakonzo akadyiswa "Cafeteria yekudya" yakawanda mumafuta uye shuga. Kupindira kwepanyama kwakasarudzwa kwakagadzirisa intestinal metabolome uye zvishoma zvakadzorerwa mazinga emakemikari ane chokuita nemafungiro akadai se. anserine, indole-3-carboxylate kana the deoxyinosine.
Plasma hormone analysis yakaratidza kuti maitiro ezvokudya akakwirira insulin uye leptin Mumhuka dzisingagari, kuita kwacho kwaideredzwa nevhiri. Uyezve, kugadziridzwa kwemahomoni akadai seGLP-1 nePYY kwakacherechedzwa zvinoenderana nekudya uye maekisesaizi, uye mhinduro dzakasimba muFGF-21. Idzi shanduko dze endocrine, dzinoenderana nemhedzisiro yekuzvibata, dzinoratidza kuti kurovedza muviri kune kudzivirira kuburikidza metabolic uye intestinal chiratidzo.
Mukufanana, vanyori vakawana kuti chikafu chemhando yakaderera chakadzora kuwedzera kwakajairika hippocampal neurogenesis kurovedza muviri, zvichiratidza kuti kuwana mabhenefiti akazara kubva mukufamba kwakakosha kutarisira hutano hwekudyaBasa rakatariswa nevezera rinopa hwaro hwakasimba hwebhayoloji yekugonesa kupindira kwemararamiro.
Spain inopa data: microbiota uye basa rehuropi kune vakura
Chikwata kubva kuCSIC, chakabatana neIMDEA Chikafu, chakaongorora 54 vanhu vane hutano pamusoro pemakore makumi mashanu nemashanu uye akawana kuti akasiyana microbiota profiles ane hukama nekusiyana kwezvinongoerekana zvaitika zvehuropi zvinoyerwa nazvo Kuzorora EEG. Misiyano yakaonekwa mune posterior medial cortical nzvimbo dzine chekuita ne chiyeuchidzo, mutauro uye kugadzirisa manzwiro.
Chidzidzo ichi chinoratidza kuti muhuwandu hwevanhu vasina neurological pathologies, kuumbwa kweiyo microbiome kunogona kukanganisa mabasa ekuziva ayo anowanzo kuderera nezera. Kubva pamaonero anoshanda, izvi zvinovhura musuwo we kupindira kwekutanga kwekudya yakanangana nekugadzirisa iyo microbiota nechinangwa che kudzivirira kana kuderedza kuderera kwekuziva zvakabatana nekuchembera.
Irritable Bowel Syndrome: Kumatapirwo Emunhu
MuSpain, Irritable Bowel Syndrome inokanganisa zvinopfuura 10% yevagari, uye ruzivo rweiyo microbiome iri kuchinja maitiro ayo. Kushandiswa kwe genomic analysis uye maturusi ehungwaru ekugadzira anobvumira kuratidza mabhakitiriya maprofile uye anoabatanidza nekuratidzwa kwekiriniki, kusimudzira modhi ye Therapeutic personalization.
Mararamiro: Kudya, kurovedza muviri, uye kurara semarevheti
Kusarudza zvatinodya nemazvo kune simba rinopfuura kugaya: muenzaniso wakapfuma mukati faibha, zvokudya zvakaviriswa uye omega-3 inotsigira microbiota uye inogona kubatsira mukugadzikana kwepfungwa. Pane zvinopesana, zvikafu zvakagadziridzwa zvine hurombo hwemhando yeshuga nemafuta zvinosanganiswa nehukuru systemic kuzvimba, mamiriro ezvinhu asina kunaka emanzwiro nekuziva.
Kudzidzira muviri kunowedzera imwe nhanho: sezvakaratidzwa nebasa reIrish, kufamba nguva dzose kunogona modulate mahormone uye metabolites kiyi, kunyangwe kana chikafu chisina kunaka. Kuwedzerwa kune izvi maitiro ezuva nezuva akadai hydration, kurara kunozorodza, uye kugadzirisa kunetseka, zvakakosha pakufamba kwakakodzera kwematumbo uye kudzivirira matambudziko akajairika akadai kupukunyuka.
Ukama huri pakati penzara yemanzwiro uye mafungiro hunotiyeuchidza kuti kudya hakusi kungoita physiology. Kudzidzira kuziva uye kugara uchidya, ne zvirongwa zvakatsiga uye migove yakaenzana, inogona kubatsira buffer kushushikana spikes, kutsigira microbial siyana uye kuchengetedza gut-brain communication nezwi rakanaka.
Mitsara mitsva yekutsvakurudza iri kuonekwa
Metabolomics zvakawanikwa zvinonongedza kune chaiwo maumbirwo emudumbu ane kufarira kwekurapa kana se biomarkers njodzi uye mhinduro. Metabolites akadai anserine kana tryptophan derivatives inobuda sezvidimbu zvekutarisa muzvidzidzo zvekushandura, nepo neurogenesis uye inoshanda yekubatanidza inobatsira chinangwa mahwindo kuyera kukanganisa.
Kufarira kuri kuwedzerawo mukati zvinhu zvakasikwa zvakapfuma mukati polyphenols ine mukana wekugadzirisa kuzvimba uye microbiota. In preclinical models Muzvirwere zveurourodegenerative, panguva imwe chete mhedzisiro yakaonekwa pahura nehuropi, mutsara wekutsvagisa unogona kuzadzisa, mune ramangwana, mazano akatarisana neiyo gut-brain axis. Senguva dzose, miedzo yekiriniki yakasimba uye magadzirirwo anofunga zvepabonde, nguva uye dose kushandura zvakawanikwa izvi mukuita.
Mufananidzo wakapendwa nezvidzidzo izvi uri kushanduka: ura nehuropi zvinochengetedza nhaurirano inogara iripo yekuti kudya, kuita zvemuviri, uye maitiro ezuva nezuva anogona kufambisa kana kukanganisa. Kuwedzera hutano hwekudya, kufamba nguva dzose, uye kutarisira kurara uye kushushikana mazinga ari kubuda senzira yechokwadi yekutsigira mararamiro ane hutano. zvakasiyana-siyana microbiota uye a hutano hwepfungwa yakawedzera kusimba, nepo microbiome-based personalization inofambira mberi muSpanish hutano hwehutano.